Organocatalysis with endogenous compounds: towards novel non-enzymatic reactions.
نویسندگان
چکیده
The aldol reaction of the endogeneous compounds acetone and methylglyoxal has been studied using organocatalysis in relation to biologically relevant non-enzymatic reactions. Under preparative conditions, 3-hydroxy-2,5-hexadione, known as Henze's ketol, is formed in high yield and with enantioselectivities up to 88% ee. Furthermore, Henze's ketol is also formed under simulated physiological conditions at micromolar scale, indicating that this reaction might take place in living organisms.
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عنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 19 14 شماره
صفحات -
تاریخ انتشار 2009